The simian line [or: 'simian crease'] has became famous for it's significance in Down's syndrome. Basically, it can be described as a 'fusion line' between the heart line and the head line (see the picture above). And it is probably the most well-known 'palmar crease'-variant. Another interesting aspect of the simian line is that the simian line also became recognized as a 'minor physical anomaly' (= MPA*).
* NOTICE: MPA's concern relatively harmless birth-marks; in some people an MPA ...
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